Genetics, Epigenetics and Psychiatric diseases

International Colloquium of the Académie des Sciences

Selon Although the human and financial costs induced by mental disorders are considerable, research in this field remains hindered: society is still reluctant to recognize that the brain may be “ill” and that metabolic anomalies may be responsible for psychiatric diseases. The colloquium held at the Académie des Sciences reviewed the place of heredity in the occurrence of mental disorders, whether involving genetic mutations, which in most cases affect, not one gene, but a multiplicity of genes, or epigenetic modifications, which may durably affect the expression of genes and be transmitted from one generation to the other .

• Introduction: Psychiatric diseases: a spectrum of phenotypes based on dysregulation of signalling networks

  Joël Bockaert, Académie des sciences, Institut de Génomique fonctionnelle, Université de Montpellier

• Disc 1 (Disturbed in Schizophrenia), schizophrenia and bipolar disorders

  David J. Porteous, Molecular Medecine Centre, Edimbourg University

• Genetics of autism

  Thomas Bourgeron, Institut Pasteur

• Genetics of mental retardation

  Jamel Chelly, Institut Cochin, Université Paris-Descartes

• Epigenetics and depression

  Dietmar Spengler, Max Planck Institute of Psychiatry, Munich

• Synaptic epigenesis and psychiatric diseases: pharmacological implications

  Jean-Pierre Changeux, Académie des Sciences, Institut Pasteur, Collège de France

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